| 2010 Nandi Awards Winners List | |
| Category | Winner |
| Best Actor | Balakrishna (Simha) |
| Best Actress | Nithya Menon (Ala Modalaindi) |
| Best Screenplay | Gowtham Menon (Ye Maya Chesave) |
| Best Editor | Kotagiri Venkateshwara Rao (Darling) |
| Best Lyricist | Nandini Siddha Reddy |
| Best Film | Vedam |
| Second best movie | Ganga Puthrulu |
| Third best movie | Prasthanam |
| Best Family Movie | Andari Banduvaya |
| Best Public Choice Film | Maryada Ramanna |
| Best Choreography | Prasad Murella |
| Best Child Movie | Little Buddha |
| Best Character Artist | Sai Kumar (Prasthanam) |
| Best Story writer | R P Patnayak |
| Best Art director | Ashok Kumar (Varudu) |
| Best Special Effects | Algar Swamy (Varudu) |
| Best dubbing artist (Male) | R C M Raju (Darling) |
| Best dubbing artist (Female) | Chimayi (Ye Maya Chesave) |
| Best Music Director | Chakri (Simha) |
| Best Play-back singer | M M Keeravani (Maryada Ramanna) |
| Best Villian | Nagineedu (Maryada Ramanna) |
| Best Supporting Actor | AVS(Kothi Mooka) |
| Best Supporting Actress | Pragathi (Ye Maya Chesave) |
| Best Comedian (Male) | Dharmavarapu Subramanyam |
| Best Comedian (Female) | Jhansi (Simha) |
| Best Director | Sunil Kumar Reddy (Ganga Puthrulu) |
| Special Jury Awards | Samantha, Sunil, Manoj |
